Study shows NMN increases in blood flow and endurance in elderly mice

A new mouse study on NMN (another NAD+ precursor nearly the same as NR) that was published today showed blood flow and endurance improved (56% to 80% for endurance) when given to older mice that were excerising but interestingly, not for the sedentary group.

Summary

A decline in capillary density and blood flow with age is a major cause of mortality and morbidity. … Treatment of mice with … (NMN) improves blood flow and increases endurance in elderly mice by promoting SIRT1-dependent increases in capillary density, an effect augmented by exercise or increasing the levels of hydrogen sulfide (H2S), a [dietary restriction (DR)] mimetic and regulator of endothelial NAD+ levels. These findings have implications for improving blood flow to organs and tissues, increasing human performance, and reestablishing a virtuous cycle of mobility in the elderly.

http://www.cell.com/cell/fulltext/S0092-8674(18)30152-1

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