So I took the NR plunge three days ago…
NR (Nicotinamide Riboside) is a Vitamin B3 derivative found in trace amounts in milk and bananas and has been shown to boost NAD+ levels in human cells. Some of you may know that my knowledge of biochemistry is, shall we say, “limited” – at best.
But Leonard Guarente at M.I.T. who founded Elysium and ‘BASIS’, which is 250 mg of NR and 50 mg of pterostelibine, says that NAD+ which goes down as you age from around 40 is important for communication between the mitochondria and other parts of the cell.
A small trial by Chromadex, the sole supplier of NR as it holds the patents of production, showed that while NAD+ increases at 100 mg, it does so more at 300 mg and that 1,000 mg doesn’t seem to be an improvement over 300 mg. (I take HPN but the brand isn’t important.) Mouse studies have been impressive, including a 2013 study that showed injecting mice with a lot of NMN (a similar NAD+ booster that is currently very expensive) had muscles in old mice revert to a much younger mouse, the human equivalent of going from 60 year old muscles to that of a 30 year old. Neat trick, and it happened in just a week.
I’m also taking 500 mg of resvertarol from Biotivia that is used in medical trials, and have pterostilbine from this past spring. (I haven’t been the most organized about this…) The six Nobel laureates who are on Elysium science advisory board take BASIS, and I will most likely follow what Guarente says he takes: 2500 mg of Vitamin D (I take 4000 mg), 81mg of aspirin, 250 mg of resveratrol and BASIS ( 250 mg of NR and 50 mg of pterostilbine found in blueberries.)
I’ll post if I turn into an excellent bald biologist.
People have reported weight loss, more energy, clearer thinking, better night vision and much lighter age spots. Three have reported to have walked on water.
Mayo Clinic and the U of Minnesota have a joint trial for traumatic brain injury victims at 2500 mg of NR, the U of Washington is starting (has started?) a trial with congestive heart failure patients — a high dose of vitamin D over a year apparently increased patients’ heart function — and other results from human studies should be out in 2017/2018.