Can NR eradicate fatty liver?

Here is a follow up to NR removing 20% of fat from those with fatty liver:

Charles Brenner, an NR expert at the U of Iowa, recently emailed someone about this study. The 2000 mg of NR a day study stopped after 12 weeks, so it isn’t clear if more fat would be removed with another 12 weeks or 24 weeks.

Brenner replied:

“There is every indication that a study setting out to clear fatty liver with high dose NR for 26 weeks would succeed.”

That is a stunning statement if he is correct. To reduce the fat in liver of those people, it would cost $200 a month at 2,000 mg of NR or $600 for the 20% reduction. So “to clear fatty liver with high dose NR” would cost $1300 over 24 weeks, which is pretty cheap to eradicate a pretty serious condition.

There is also reason based on previous studies that note NAD+ levels drop significantly at doses over 500 mg to think maybe only 1000 mg of NR would be is as effective as 2000 mg so then the cost would be just $700.

30 million Americans have non-alcoholic fatty liver at a more serious stage.

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NR reduced fat in liver of obese men by 10 percent

Dr. Drew interviewed Charles Brenner who said that the NR Copenhagen trial to be released soon shows a 10% decline in fat in the liver of obese men from 11% to 10%.
The subjects took 2000 mg of NR for 12 weeks, but it isn’t clear that much is needed based on the first Elysium trial.

(Podcast #333)

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“We should stop training radiologists right now!”

“They should stop training radiologists now. It’s just completely obvious within five years that deep learning is going to do better than radiologists. It might take ten years, but we’ve got plenty of radiologists already. I said this at a hospital, and it didn’t go down to well.”

— deep learning expert Geoff Hinton, 2017

In 2007, I asked a friend who is a radiologist and was 42 at the time when he planned to retire, and he thought about it and said 2027. I replied that weak A.I. pattern recognition will continue along the exponential computer power path and that his job won’t be around closer to 2017 than 2027. He said “no way.” We’ll see…

Hinton’s quote

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The U of Colorado-Boulder NR trial results have been released

The U of Colorado-Boulder NR trial results were released last week and showed promising results for those taking 1,000 mg of NR (Nicotinamide Riboside), a derivative of vitamin B3, a day for six weeks. (The Elysium study released last December suggests little increase in NAD+ levels above 500 mg a day, beyond eight weeks.)

First, it looks like NR improved flexiblity in the aurota among healthy non-obese people. Second, NR lowered the systoic blood pressure by an average of 10 points among those with pre-hypertension but not in adults aged 55 to 79 with normal blood pressure.

Chris Martens at the U of Delaware stated: “What this paper provides us with is a really good stepping stone for future work.”

The U of Colorado article also mentions that Martens is preparing a new trial on older adults with mild cognitive impairment.

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Tyler Cowen on the Manhatten Project and the Apollo Mission

Economist Tyler Cowen who predicted in 2009 that a) The U.S. will have slow growth until the 2040s because “the low hanging fruit has been picked”* and b) there will be no medical breakthroughs before 2030.

Recently, Cowen was interviewed on a podcast where he discussed how complacent America has become and mentioned the Manhatten Project and the Appolo Mission and that current bureacracy would make both impossible today. Here are some errors I responded to on his Marginal Revolution blog:

1. Tyler Cowen: “Compare that to the 1920s when there were incredible revolutions in communication: radio, telephone, later the television.”

The telephone was invented decades before it took off and was still owned by just 15% in 1920 and 20% in 1929. The radio went from 0% to 15% in the 1920s and the television wasn’t on the radar until the early 1950s. Diffusion rates of personal computers, VCRs, DVD players, the internet, broadband, MP3 players, cell phones, smart phones, facebook and the ipad have been much quicker.

2. “The Manhatten Project cost several percentage points of GDP at its peak.”

The Manhatten Project cost $2 billion (nominal) over 4 years. The GDP then was around $200 billion (nominal) so around 0.25 percent of GDP during those four years, not several percent.

3. “And then to put a man on the moon in basically 7 years from scratch. We can’t even build a bridge in 7 years or 17 years…”

It wasn’t from scratch. The Appollo Mission was proposed by Eisenhower in 1960 as a follow up to Project Mercury that began in 1958. So a minimum of 11 years, not including previous missile technology.

* (It wasn’t low picking fruit at the time of past incrememtal innovation)

p. 7 on technological diffusion

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The New York Times on Japan – Remember the trade wars of the 1980s? Neither do I.

The New York Times ran an article on Trump’s tariffs and how they relate to Japan, but it has three notable inacurracies:

1) The NY Times mentions: “the trade wars between the two countries.” What trade wars? There was the voluntary restriction on exporting autos to the U.S. when there was a deep recession in the early 80s, a 45% tarrif on motorcycles that Japan could completely avoid so hurt nobody. The U.S. put up a 100% tarrif on Japanese medium sized televesions, computers and semiconductors for $300 millon worth of importrs in 1987 dollars. That increased some prices in the U.S. but hardly came close to a trade war. The threat the media played up then was that those actions might cause a trade war.

2)Japan analyst Tobias Harris was quoted as saying that economic friction between the U.S. and Japan goes back to the 70s “and is more the rule than the exception.”

Apart from a little trade friction in the 70s, it was only a mid 80s to early 90s issue but when has there been friction after 1995? That is 22 years, friction free.

3) A political scientist at Sophia University was quoted as saying American voters have a bad image of Japan. Last month, a Gallup poll 87% of Americans had a favorable image of Japan and has been over at 80% or over since 2005.

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Study shows NMN increases in blood flow and endurance in elderly mice

A new mouse study on NMN (another NAD+ precursor nearly the same as NR) that was published today showed blood flow and endurance improved (56% to 80% for endurance) when given to older mice that were excerising but interestingly, not for the sedentary group.


A decline in capillary density and blood flow with age is a major cause of mortality and morbidity. … Treatment of mice with … (NMN) improves blood flow and increases endurance in elderly mice by promoting SIRT1-dependent increases in capillary density, an effect augmented by exercise or increasing the levels of hydrogen sulfide (H2S), a [dietary restriction (DR)] mimetic and regulator of endothelial NAD+ levels. These findings have implications for improving blood flow to organs and tissues, increasing human performance, and reestablishing a virtuous cycle of mobility in the elderly.

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